In addition, knock-down of the rars2 (arginyl-tRNA synthetase 2) gene, which has been also related to pontocerebellar hypoplasia type 6, resulted in a similar brain phenotype to that observed in tsen54 morphants, which was also partially rescued by the co-injection of RARS2 human mRNA [127]. The gene discussed is TSEN54; the disease is pontocerebellar hypoplasia type 6.