Similarly, knock-down of cspp1 (centrosome and spindle pole associated protein 1), cep104 (centrosomal protein 104), kiaa0556 (katanin interacting protein) and poc1b (proteome of the centriole 1B) in zebrafish resulted in a ciliopathy phenotype, which is characteristic of Joubert syndrome [121,122,123,124,125,126]. The gene discussed is POC1B; the disease is Joubert syndrome.