In support of this hypothesis, recently in human medicine, it has been demonstrated that both necroptosis and the RIP3-dependent NLRP3 inflammasome pathways are activated in podocytes during lupus nephritis [28], likewise a type I immunity has been associated with keratinocyte necroptosis in lichen planus and lupus erythematosus, two forms of interface dermatitis [29]. This evidence concerns the gene NLRP3 and lupus nephritis.