In another mouse model of DCM, tet-off bigenic mice expressing lamin (D300N) mutant protein in cardiac myocytes [61], a significant downregulation of retinoblastoma (RB) expression has been found, accompanied by transcriptional upregulation of other loci, Cdkn2a included, supporting the role of p16INK4a in heart dysfunction [62]. Here, CDKN2A is linked to familial dilated cardiomyopathy.