The positive effect of basophilia in CRC is most likely related to the secretion of basophil granules content, including histamine and proinflammatory cytokines—e.g., TNFα, IL-6, and IL-1β—augmenting inflammatory reaction, recruitment of cancer-specific CD8+ T cells into the tumor and increasing cancer cell apoptosis [38]. This evidence concerns the gene IL6 and colorectal carcinoma.