In this regard, incubation of female VLCAD−/− mouse fibroblasts with C8 has led to the activation of the ERK/mTORc1 pathway and, subsequently, of lipogenesis [42], corroborating the previously reported sex-specific development of a metabolic syndrome in female VLCAD−/− mice after prolonged MCT supplementation [35]. Here, MCAT is linked to metabolic syndrome.