MAPT and Alzheimer disease: PLGA–PEG NPs conjugated with B6 peptide increased the delivery of curcumin into the CNS in an AD mouse model, showing a reduced expression of hallmark AD pathological markers, including amyloid-beta, presenilin-1, phosphorylated tau, and beta-secretase 1, compared to curcumin alone or NPs without B6 peptide [83].