um-PEA is able to inhibit the release and action of mast cells, reduce the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) [34], and counteract the release of proinflammatory proteases, histamine, cytokines, and chemokines (also implicated in COVID-19) [35,36]. Here, PTGS2 is linked to COVID-19.