AKT1 and infection: Consistent with the molecular functions data, the primary biological pathways cataloged on KEGG (complete data, Supplementary File D) also unveiled the connection of the host defense pathways to the downregulated miRNAs during the initial stage of ZEBOV strains infection (Mayinga, PI3k-Akt signaling pathway, cAMP signaling pathway; Makona, T-cell receptor signaling pathway, proteasome, Fc gamma R-mediated phagocytosis) (Figure S10, left panel, 24 h).