SIPA1 promotes the adhesion, migration and invasion of breast cancer MDA-MB-231 cells by binding to the promoter region of ITGB1 (integrin β1) gene and activating it, thus stimulating the downstream integrin mediated focal adhesion kinase/Protein kinase B/matrix metalloproteinase 9 (FAK/Akt-MMP9) pathway [23]. Here, MMP9 is linked to breast cancer.