The contribution of CCT/TRiC to cancer has not received much attention, but evidence of it is now emerging, since it also mediates the folding and function of client proteins related to oncogenesis, such as the Von Hippel-Lindau and p53 tumor-suppressor proteins, the telomerase cofactor TCAB1 and STAT3 oncoproteins, and several cell cycle regulators [88]. This evidence concerns the gene TP53 and cancer.