CXCL12 and neuroblastoma: Indeed, studies have found that MSCs isolated from neuroblastoma tumors carried transcriptomic profiles associated with EMT, which in turn were associated with poor prognosis, and expressed high levels of C-X-C Motif Chemokine Ligand 12 (CXCL12), promoting neuroblastoma metastasis and invasiveness [27,28,29].