AGER and colon carcinoma: Another activator of MDSC is the highly proinflammatory alarmin S100A8/A9 complex, which has been demonstrated to activate Nuclear Factor Kappa B (NF-κB) and STAT3 pathways by binding TLR4 and carboxylated N-glycans on the receptor for advanced glycation end products (RAGE) on MDSC in colon carcinoma-bearing mice [78,127].