Progression of neuroblastoma and other solid tumors is promoted by TAMs through the secretion of factors like VEGF, Platelet-derived growth factor (PDGF), TGF-β, MMP2, and MMP9, which lead to extracellular matrix remodeling and increased neoangiogenesis [97,98] (Figure 2). Here, TGFB1 is linked to neuroblastoma.