Twenty studies reported an association between HTN and genes such as ACE, AGT, AGTR1, ANP, APOA5, ARGHGAP42, ATP2B1, B2, BAG6, CABCOCO1, CACNB2, CAND1, CHIC2, CNNM2, CPS1, CSK, CYP11B2, CYP2C8, EBF1, FES, FGF5, GNB3, GOSR2, GRK4, GUCY1A1N, HFE, IGFBP3, JAG1, LEP, MECOM, MOV10, MTHFR, NOS3, PLCE1, PLEKHA7, PR3, SH2B3, SLC39A8, SLC4A7, STK39, SUB1, TBX5, ULK4, ZNF652, and ZNF831 whereas twenty-two studies did not show any association (Table 2). The gene discussed is GRK4; the disease is hypertensive disorder.