ACE and hypertensive disorder: Only 14 genes (CYP2C8, CYP11B2, AGT, AGTR1, AGTR2, ACE, ADRB2, LEP, MTHFR, NOS3, HFE, CNNM3, IGF2BP2, and SCNN1B) were identified to have an interaction with FDA approved marketed HTN drugs (Figure 3 and Table S4).