Figure 8 shows that certain genes are shared among different sub-types of HTN and there are genes which contribute to a specific sub-type of the disease. For example, CLCNKB is only linked to TRH, therefore, a drug targeting this gene will be effective in treating salt sensitive HTN, since a polymorphism in this gene leads to increased salt retention in the bloodstream. Similarly, the gene such as ACE is linked to almost all categories of diseases shown in Figure 8, thus pointing towards its universal role in HTN related diseases. This evidence concerns the gene TRH and hypertensive disorder.