Only 14 genes (CYP2C8, CYP11B2, AGT, AGTR1, AGTR2, ACE, ADRB2, LEP, MTHFR, NOS3, HFE, CNNM3, IGF2BP2, and SCNN1B) were identified to have an interaction with FDA approved marketed HTN drugs (Figure 3 and Table S4). The gene discussed is HFE; the disease is hypertensive disorder.