Twenty studies reported an association between HTN and genes such as ACE, AGT, AGTR1, ANP, APOA5, ARGHGAP42, ATP2B1, B2, BAG6, CABCOCO1, CACNB2, CAND1, CHIC2, CNNM2, CPS1, CSK, CYP11B2, CYP2C8, EBF1, FES, FGF5, GNB3, GOSR2, GRK4, GUCY1A1N, HFE, IGFBP3, JAG1, LEP, MECOM, MOV10, MTHFR, NOS3, PLCE1, PLEKHA7, PR3, SH2B3, SLC39A8, SLC4A7, STK39, SUB1, TBX5, ULK4, ZNF652, and ZNF831 whereas twenty-two studies did not show any association (Table 2). Here, IGFBP3 is linked to hypertensive disorder.