We found that berbamine, a natural agent that has been used as a traditional medicine in clinics to ameliorate leukopenia caused by cancer radiotherapy and chemotherapy [39], could inhibit the induction of CREB/ATF1 phosphorylation by aspirin in HepG2 and Hep3B cells (Figure 5b). The gene discussed is CREB1; the disease is Decreased total leukocyte count.