miR-22 inhibits phosphatidylinositol 3-kinase (PI3K)/Akt/NF-κB signaling via downregulating activators such as S100A8, platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF), which implies a tumor suppressor role of miR-22 in tongue squamous cell carcinoma [191]. This evidence concerns the gene VEGFA and tongue squamous cell carcinoma.