miR-488-3p activates the p53 pathway through suppressing zinc finger and BTB domain-containing protein 2 (ZBTB2), a reader of unmethylated DNA that regulates embryonic stem cell differentiation, thereby inhibiting proliferation and inducing apoptosis in esophageal SCCs [224,225]. The gene discussed is ZBTB2; the disease is esophageal squamous cell carcinoma.