In an attempt to identify proteins that display low or no expression in low-grade astrocytomas but a high level in GBM, a cancer-related and multifunctional glycoprotein FN was specially chosen and examined according to the mining of the Human Protein Atlas database (https://www.proteinatlas.org/, accessed on 1 November 2017). The gene discussed is FN1; the disease is glioblastoma.