A recent study reported that the induction of EGFR-mediated carbon monoxide-releasing molecule-2 (CORM-2) in human bronchial smooth muscle cells promotes HO-1 expression, whereas in glioblastoma, the phosphoinositide 3-kinase (PI3K) signaling pathway is activated through the binding of EGFR and EGF to induce HO-1 expression [19,20,27]. This evidence concerns the gene EGF and glioblastoma.