Thrombocytopenia in liver disease results from increased splenic sequestration due to portal hypertension and subsequent hypersplenism [7,8,13,16], decreased thrombopoietin (TPO) production [6,17,18,19], and/or from toxic or virus-induced suppression of megakaryocytopoiesis [6,19,20,21]. The gene discussed is TPO; the disease is liver disorder.