SENP1 and neoplasm: Even though it directly targets oncogenes such as GLUT-1, which are studied in this paper, it has been shown to directly target tumor suppressor genes such as caspase 10 and epiregulin (inhibiting cell apoptosis and increasing cell proliferation), RETREG 1 (inducing G1-S transition and migration), APAF-1 (inducing invasion), PPM1B (promoting G1-S transition and proliferation) and SENP1 (promoting NF-kB pathway and inducing tumor invasion) [36].