IL5 and Increased total eosinophil count: ILC2 activation and resultant Th2 cytokine release is now considered a key event in type 2 inflammatory diseases, with the production and release of IL-5 resulting in eosinophilia, IL-13 resulting in airway mucus production and remodeling, and IL-9 promoting goblet cell hyperplasia and mastocytosis [141,163,164,165].