In contrast to the results observed in MIA-PaCa-2 PDAC cells, where WT-GSK-3β acted as a tumor promoter and KD-GSK-3β functioned as a tumor suppressor, in MCF-7 breast cancer cells, KD-GSK-3β functioned as a tumor promoter and WT-GSK-3β functioned as a tumor suppressor. Here, GSK3B is linked to neoplasm.