Addition of a suboptimal concentration of berberine reduced the IC50 concentration of tideglusib in both MCF-7 + pLXSN and MCF-7 + KD-GSK-3β cells, 2.3- and 333-fold, respectively, but increased the IC50 in MCF-7 + WT-GSK-3β cells 111-fold indicating that GSK-3 was playing a tumor suppressor role in these cells, and berberine could not function to decrease cell growth in the presence of WT-GSK-3β expression (Figure 22, Table 3). Here, GSK3B is linked to neoplasm.