GSK3B and type 2 diabetes mellitus: The abilities of MIA-PaCa-2 + WT-GSK-3β, MIA-PaCa-2 + KD-GSK-3β, and MIA-PaCa-2 + pLXSN to form colonies in the presences of a GSK-3 inhibitor, the type II diabetes drug metformin, and the nutraceutical berberine were also determined (Figure 12, Panels A, B, and C).