AKT1 and neoplasm: Although the implicated molecules have not been identified, the activation of AKT, STAT5α, GSK3β, ERK1/2, and NF-kB pathways in adipocytes treated with tumor-derived exosomes, as analyzed by phosphoproteomics and Western blot, was demonstrated, supporting the relevance of these pathways and the exosome method of cell–cell interaction in the dedifferentiation process [86].