PLOD2 and breast cancer: In detail, tumor-derived plasminogen activator inhibitor 1 (PAI-1), through the induction of the PI3K/AKT pathway in CAAs, activates the expression of procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 (PLOD2) that induces the alignment of collagen I fibers, further promoting BC metastasis.