Epigenetic changes such as H3K27ac modifications, exosomal miRNA expression of miR-211-3p, 6826-3p, 1236-3p, and 4448, and the increase of vascular endothelial growth factor (VEGF) and angiopoietin-2 levels after DAA treatment have also been reported to increase HCC recurrence risk [102,103,104]. Here, VEGFA is linked to hepatocellular carcinoma.