Moreover, we observed variation in PPM1D levels among cytogenetic subgroups (Kruskal Wallis test, TCGA p = 0.031; GSE13159, p < 0.001, Figure 1A), with higher expression in t(8;21) and inv(16)/t(16;16) cases and lower expression in normal karyotype AML in both the two independent cohorts. This evidence concerns the gene PPM1D and acute myeloid leukemia.