CCAR1 and colonic neoplasm: CARP1 has been shown to be involved in NR3A (NMDA-type glutamate receptor subunit) synaptic signaling, along with regulating β-catenin in colon cancer metastasis, co-activating GR (glucocorticoid receptor) signaling during adipogenesis, or neurogenin3-mediated pancreatic endocrine differentiation [47,48,49,50].