Inflammatory cytokines, such as IL-6, IL-1β, and IFN-γ that are elevated in the biospecimen of COVID-19 patients, can activate the Janus kinase (JAK)/signal transducer of activators of transcription (STAT) JAK/STAT pathway and induce the NF-kB signaling (Figure 1). This evidence concerns the gene IL1B and COVID-19.