Notably, key tumor-suppressive pathways were downregulated, such as p53 (Bcl2, Bcl2l1, Ccnd1, Cdkn1a), PTEN (Ikbke, Iitga2, Iitga4, Ntrk2), and apoptosis (Bcl2, Bcl2l1, Capn11, Capn8). This evidence concerns the gene IKBKE and neoplasm.