The analysis of the 62 orthologous genes in the human TCGA database identified 4 genes differentially overexpressed related to high lipid overload with potential relevance in tumor promotion: Mthfd1l, (W/DEN: 2.74- and HC/DEN: 2.42-fold change) Slc41a3, (W/DEN: 2.67- and HC/DEN: 1.70-fold change), Fabp5 (W/DEN: 2.20- and HC/DEN: 2.70-fold change); and Igdcc4, (W/DEN: 2.05- and HC/DEN: 1.88-fold change increased) in W/DEN and HC/DEN, respectively comparing with CW/DEN. The gene discussed is MTHFD1L; the disease is neoplasm.