In different cancer cell lines, DDR1 promotes survival by regulating the Ras/Raf/MEK/MAPK (Rat sarcoma/Rapidly Accelerated Fibrosarcoma/Mitogen-activated protein kinase kinase/Mitogen-activated protein kinase) pathway, resulting in positive feedback on the expression of the tumor suppressor P53 and the activation of AKT [34]. The gene discussed is WNK2; the disease is sarcoma.