DDR2 expressed by cells of the TME is also involved in collagen remodeling.Inhibition of DDR2 in CAFs or in mesenchymal stem cells impacts their mechanotransduction function, disturbs collagen fiber organization, and decreases matrix stiffness and TACS-3 signature, leading to inhibition of breast tumor cell invasion [97,99]. Here, DDR2 is linked to breast neoplasm.