In human A375 melanoma, HT29 colon carcinoma and SK-HEP hepatoma cells, inhibition of DDR1 reduces by 75% very early tumor cell adhesion to collagen I with significant impairment of the cell–cell adhesion molecules ICAM1 (InterCellular Adhesion Molecule 1) and VCAM1 (vascular cell adhesion molecule 1) [110]. This evidence concerns the gene VCAM1 and melanoma.