TP53 and neoplasm: To better elucidate the potential regulation mechanisms of leucocyte intraluminal crawling in tumour environment during post-irradiation tumour growth, RNA-seq analysis was used and it was shown that enrichment for leucocyte locomotion-associated genes closely correlated with TRP53-regulated, radiation-induced endothelial-to-mesenchymal transition (EndMT), which has been reported to be involved in disruption of endothelial barrier and loss of endothelial adhesion molecules [77,78].