In HEVhigh tumours compared with HEVlow tumours, gene profile of HEVs has shown upregulation of genes encoding lymphoid chemokines including chemokine (C-C motif) ligand (CCL) 19 (CCL19), CCL21, and CXCL13 as well as T-cell homing receptors (CCR7 and LSEL) [170]. Here, CCR7 is linked to neoplasm.