This classification identifies four main subdivisions based on the level of expression of ASCL1 (achaete-scute homolog 1), classified as SCLC-A; NEUROD1 (neurogenic differentiation factor one), classified as SCLC-N; POU2F3 (pou class 2 homeobox 3), classified as SCLC-P; YAP1 (yes-associated protein 1), classified as SCLC-Y. Here, POU2F3 is linked to small cell lung carcinoma.