Erns and E2 are the most immunogenic proteins of BVDV and induce high titers of protective neutralizing antibodies after infection; several studies based on vaccination with Erns and E2 glycoprotein expressed in different systems have been reported [37,38,39,40,41], Chimeno Zoth S used BEVS to express the E2 protein of the BVDV NADL strain, proving that the recombinant E2 protein vaccine can elicit an in vitro neutralizing humoral immune response, not only against the homologous strain, but also against heterologous BVDV strains [37]. The gene discussed is UBE2B; the disease is infection.