Emerging evidence suggests that tumor-derived (TD) exosomes provide a soil conducive to tumor growth by mediating communication within the tumor microenvironment, i.e., exosomal miR-105 released from the BC cell lines MCF-10A and MDA-MB-231 dissolve endothelial cells identity by weakening Zonula occludens 1 (ZO-1) gene expression which promotes metastases of cancer daughter cells to the lung and brain [24]. This evidence concerns the gene TJP1 and breast cancer.