IL6 and breast cancer: By establishing an animal model of BC in mice, Kong et al. demonstrated that exosomal miR-155 regulates the von Hippel-Lindau (VHL)/hypoxia-inducible factor (HIF) axis and a cohort of downstream genes, such as interleukin 6 (IL6), vascular endothelial growth factor A (VEGFA), CD44, and pyruvate kinase isozyme type M2 (PKM2), to motivate angiogenetic cascades [111].