BCHE and lung carcinoma: The novel derivatives were then tested for their inhibition effect on human recombinant AChE (hAChE)/human recombinant BChE (hBChE), ability to cross the BBB, antiproliferative activity on human lung carcinoma cell line (A549), selectivity towards normal colon fibroblast cell line (CCD-18Co), and detailed molecular modelling studies.