The selective inclusion of patients with advanced hepatic impairment (i.e., CTP stages B/C) in the study by Dunn and colleagues [37] may have also obscured a potential link between PNPLA3 genotype and BL severity of liver disease (i.e., liver disease progression), since CTP A cirrhosis could have been more common in those without a G-allele, as observed in our cohort of unselected ACLD patients. This evidence concerns the gene PNPLA3 and Cirrhosis.