These include genes involved in the regulation of the cell cycle and apoptosis such as the proto-oncogene Myc as well as Anln and Bcl2, and genes known to be upregulated in response to cardiac hypertrophy such as Acta1. cKO samples showed a significant downregulation of the proapoptotic factor Egln3. Similar genes were significantly differentially expressed when comparing cKO mice with a stress score of 1 to control mice and unstressed cKO mice (Supplementary Figure S5). Here, MYC is linked to cardiac hypertrophy.