In this frame, the selective CB1 ligand VIAcX, featuring the 4,5-dihydro-1H-benzo(2,3)oxepino(4,5-c)pyrazole core, exhibiting neutral antagonist profile, effectively reduced body weight with the improvement of cardiovascular risk factor in C57BL/6N diet-induced obesity (DIO) mice fed with fat diet. This evidence concerns the gene CNR1 and Obesity.