It is clear that most of the benign lesions present the alteration of v-Raf murine sarcoma viral oncogene homolog B (BRAF) in the codon V600E (sufficient for the nevus formation); but, for melanoma development, BRAF mutation is not sufficient because the disease progression is bound to concomitant alteration in other genes involved in the most important cellular processes [6,7]. The gene discussed is BRAF; the disease is melanoma.