MTOR and Cognitive impairment: Of note, 5-HT6 receptors can be targeted by alternative ligands, like ∆9-tetrahydrocannabinol (THC), whose chronic administration induces a long-lasting activation of mechanistic target of rapamycin (mTOR) in juvenile prefrontal cortex (PFC), leading to cognitive deficits in adulthood, at least in mice [74].