TLR2 and chronic kidney disease: In a murine model of CKD-extraosseous calcification, supplementation with MK-7 (100 μg/g diet) inhibited the development of cardiovascular calcification via MGP pathway [71], whereas Wang and collaborators [138] found that this compound could inhibit the intimal calcification of the aortic artery in a high-fat diet in ApoE−/− mice model through the downregulation of the Toll-like receptor 2 (TLR2) and TLR4 expression.