Of note, similar high BTLA/HVEM mRNA expression levels were observed in CLL, acute myeloid leukemia (AML), multiple myeloma (MM) and DLBCL, suggesting that BTLA/HVEM axis may also play a role in the pathogenesis of these malignancies (Figure S3). This evidence concerns the gene TNFRSF14 and B-cell chronic lymphocytic leukemia.