FAN1 and neoplasm: Nine cases with germline variants in HR-related genes PALB2, BRCA1, RAD51C, FAN1 and CHEK2 also showed evidence of enrichment of the germline variant in the tumor, while the other 12 cases with HR-related gene variants (seven FAN1, three CHEK2, one BRIP1, one NBN) did not (Figure 1).