PDPN and colonic neoplasm: Two prognostic colon cancer biomarkers, namely podoplanin [20] and exosome component 5 (EXOSC5) [21], have been chosen to further verify tumor and normal tissue specimens: podoplanin mRNA level was significantly increased by 10-fold in tumor samples (Figure 3a,b), and EXOSC5 by even 20-fold (Figure 3c,d).