RUNX3 and hepatocellular carcinoma: One study examined DNA hypermethylation of seven tumor-related genes, including APC, WIF1, RUNX3, DLC1, SFRP1, DKK, and E-cad, in HCC patients, and showed that the hypermethylation status of those seven genes in HCC tissues, as defined by extent of CpG island methylation, differs significantly between male and female patients.