MGMT and hepatocellular carcinoma: Another meta-analysis study reported a weak (non-significant) association between O6-MGMT methylation and HCC risk in a Chinese population (OR: 2.42 with a 95% CI (confidence interval) of 0.76–7.73) but not in a Western population (OR: 0.06) [79], which supports that O6-MGMT methylation changes are unlikely to play a role in HCC disparities.