MTHFR and hepatocellular carcinoma: Notably, Qiao et al. reported that the MTHFR C677T variant is associated with lower LINE1 methylation, more so in women than in men, and that women have less LINE1 methylation compared to men in both chronic HBV and HCC, suggesting that LINE1 hypomethylation may be a more relevant pathogenic mechanism in female HCC patients with these MTHFR variants than in male patients [60].