CDKN2A and hepatocellular carcinoma: Herath et al. also examined the promoter methylation status of another six genes, including p16INK4A (CDKN2A), p14ARF (CDKN2A), and p15INK4B (CDKN2B), using the methylation-specific PCR (MSP) approach and the same Australian and South African HCC and ANT samples as described above.