DNMT3B and hepatocellular carcinoma: In addition, the same -149 T polymorphism of DNMT3B, which is associated with an increased risk of HCC development in a sex-dependent manner in a Moroccan population [39], also shows different prevalence in different populations, with the Moroccan population being the lowest (16% for homozygous TT), followed by an American NHW population (22%) [84] and a Chinese population (98%) [85].