Further subgroup analysis by ethnicity showed that promoter methylation of these two genes is specifically associated with HCC risk in Asians (OR: 34.7 (GSTP1), 29.0 (SOCS1)) and NHWs (OR: 8.9 (GSTP1), 5.3 (SOCS1)) [75]. The gene discussed is SOCS1; the disease is hepatocellular carcinoma.