Another study examined the methylation status of CpG islands associated with 19 genes found to be hypermethylated in HCC compared to normal tissue, including HOXA1, CDKN1C, CRABP1, DLEC1, p16INK4A, CCND2, CACNA1G, RUNX3, PTGS2, BCL2, GRIN2B, NEUROG1, GSTP1, SYK, SFRP1, CALCA, SOCS3, APC, and TERT. This evidence concerns the gene RUNX3 and hepatocellular carcinoma.