To this end, we grouped CRC cell lines based on their molecular features including microsatellite instability (MSI vs. MSS, Figure 4A and Figure S4A), CpG island methylator phenotype (CIMP-high vs. CIMP-low, Figure 4B and Figure S4B), and five most common gene mutations in CRC (APC, KRAS, BRAF, TP53, PIK3CA mutant vs. wild type, Figure 4C–G and Figure S4C–G). Here, PIK3CA is linked to colorectal carcinoma.