TP53 and colorectal carcinoma: To this end, we grouped CRC cell lines based on their molecular features including microsatellite instability (MSI vs. MSS, Figure 4A and Figure S4A), CpG island methylator phenotype (CIMP-high vs. CIMP-low, Figure 4B and Figure S4B), and five most common gene mutations in CRC (APC, KRAS, BRAF, TP53, PIK3CA mutant vs. wild type, Figure 4C–G and Figure S4C–G).