A study conducted by Guo et al. demonstrated that miR-196b suppressed proliferation, migration and invasion of human choriocarcinoma cells by inhibiting its transcriptional target MAP3K1. miR-196b and MAP3K1 may be considered potential targets for the clinical treatment of hydatidiform mole and possibly human choriocarcinoma [125]. This evidence concerns the gene MAP3K1 and hydatidiform mole.