Indeed, in this group, TNF-α, IL-1b and IL-10 levels were higher in patients who worsened than in those who improved with poor to sufficient predictive value (AUROCs 0.66, 0.71 and 0.72, respectively); (4) CRP, PCT, and TPO levels had significant predictive value only in the group of patients with severe sepsis. This evidence concerns the gene TNF and Sepsis.