SPINK1 and pancreatic neoplasm: Patients with chronic pancreatitis (CP) due to the SPINK1 gene mutation c.101A>G (p. N34S) detected by pyrosequencing were reported to have a 12-fold higher risk of developing pancreatic cancer than controls (Cox HR: 12.0 (3.0–47.8); p < 0.001) [20,21].