Th1 cytokines, such as interferon (IFN)γ, interleukin (IL)-1α, IL-1β, Il-2, tumor necrosis factor (TNF)-α, and TNF-β, trigger thyrocyte destruction by CD8+ cytotoxic cells, which ultimately leads to gland atrophy and hypothyroidism [3]. The gene discussed is TNF; the disease is hypothyroidism.