Several studies elucidated the main consequences of NF-kβ activation, including enhancing invasiveness of tumors, promoting cell detachment, increasing neoangiogenesis, upregulating MMPs expression, inducing tumor proliferation, polarization of tumor cells, production, and overexpression of inflammatory reparative response, which is ultimately causing further development of tumors [337]. Here, NFKB1 is linked to neoplasm.