Furthermore, in human adenocarcinoma MCF-7 cells, TQ induced apoptosis, by disrupting mitochondrial membrane potential and activating caspases and PARP cleavage and increasing Bax/Bcl2 ratio, arrested cell cycle at G2/M and sub-G1 phase via the modulation of the Akt/PTEN axis [42]. Here, BCL2 is linked to adenocarcinoma.