CASP3 and osteosarcoma: For example, TQ decreased chemoresistance and angiogenesis through blocking NF-κβ activation, DNA-binding activity, survivin and VEGF and increased the expression of cleaved caspase-3 and Smac in human osteosarcoma cells SaOS-2121; these results were confirmed in an in vivo study on male athymic BALB/c nu/nu mice treated with TQ, where it was able to prevent tumor angiogenesis and inhibit osteosarcoma growth through decreasing the expression of inhibitor of apoptosis proteins, VEGF, prosurvival molecules, such as survivin and XIAP, and proliferation markers, including CD34 and Ki-67 [103].