BCL2 and familial pancreatic carcinoma: Additionally, in different human pancreatic cancer cells (MiaPaCa-2, BxPC-3, AsPC-1 and HPAC), TQ-4A1, TQ-5A1 and TQ-2G analogs showed more potent antiproliferative activity than parental TQ by reducing cell viability, stimulating apoptosis through the downregulation of Bcl-2, survivin and upregulation of Bax/Bcl-2 ratio and reducing COX-1 and COX-2 enzyme activity without any toxic effects on the normal cell [67,68].