Recent studies suggested that TQ with Gemcitabine led to considerable reduction of cell proliferation, induction of apoptosis, necrosis and autophagy in and pancreatic cancer PANC-1 and Mia PaCa-2 cells via increasing caspase 3, PARP cleavage, downregulating PKM2, reducing cell viability and regulating two independent microRNA (miR-101 or miR-24-2) [114]. Here, CASP3 is linked to pancreatic neoplasm.