For example, in human adenocarcinoma FG/COLO357 and CD18/HPAF81 cells, TQ was able to promote apoptosis, decrease motility and migration by reducing MUC4 and Bcl-xL expression via the activation of c-Jun NH2-terminal kinase and p38 pathways [65], while in human pancreatic carcinoma HS766T cells TQ from N. sativa oil extract induced a antiproliferative effect, by upregulating p21 expression, suppressing histone deacetylase activity, decreasing MCP-1, TNF-α, IL-1b and Cox-2 via NF-kβ modulation [66]. This evidence concerns the gene NFKB1 and adenocarcinoma.