FAS and plasma cell myeloma: Moreover, in IL-6–dependent human MDN, XG-2 cell lines, TQ showed chemopreventive and chemotherapeutic effects through the inhibition of CXCL12 mediated chemotaxis and the downregulation of CXCR4 expression and increased CD95 levels and susceptibility to Fas-mediated apoptosis in primary cells isolated from multiple myeloma patients without inducing any apoptotic effect on peripheral blood mononuclear cells from healthy donors [82].