Furthermore, an analog of TQ induced apoptosis by downregulating Bcl-2, Bcl-xL, survivin, XIAP, COX-2 combined with Gemcitabine and oxaliplatin in Gemcitabine resistant pancreatic cancer MiaPaCa-2 cells [67,68]. This evidence concerns the gene BIRC5 and familial pancreatic carcinoma.