Moreover, in different human leukemia cells, including Kasumi-1, MV4-11, THP-1 and ML-1 cells, TQ inhibited DNA (cytosine-5)-methyltransferase 1 (DNMT1) methylation activity via breakdown of the Sp1/NF-kB complex from the DNMT1 promoter, reduced colony formation and promoted cell apoptosis through activation of caspases [79]. The gene discussed is DNMT1; the disease is leukemia.