TNF and neoplasm: Interestingly, TAMs are mobilized to the peripheral blood and then recruited in the PMNs by many tumor-secreted cytokines and growth factors (e.g., CCL2, CSF-1, VEGF, PLGF, TNF-α, TGF-β), tissue inhibitor of metallopeptidase (TIMP)-1, and exosomes [37,39,40].