In particular, the interaction between cancer and stromal tissue may result in the activation of CAFs [73]; when activated, these cells are able to produce soluble molecules, such as TGF-β, fibroblast growth factor (bFGF), platelet-derived growth factor (PDGF), interleukins, and molecules of the vascular endothelial growth factor (VEGF) family [74]. Here, VEGFA is linked to cancer.